Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.

@article{Ferraz1997InductionOC,
  title={Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.},
  author={Jos{\'e} Geraldo P Ferraz and Keith A Sharkey and Brian K. Reuter and Samuel Asfaha and A W Tigley and Manuel L. Brown and W. F. McKnight and John L Wallace},
  journal={Gastroenterology},
  year={1997},
  volume={113 1},
  pages={195-204}
}
BACKGROUND & AIMS Prostaglandins and nitric oxide are key mediators of gastric mucosal defense. Endotoxemia alters gastric resistance to damage, but little is known of the effects of chronic endotoxemia on the expression of prostaglandin and nitric oxide synthases (NOSs). The effects of short- vs. long-term administration of endotoxin on gastric resistance to damage and on expression of NOS and prostaglandin synthesis were compared. METHODS Rats were treated with short- or long-term bacterial… CONTINUE READING