Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.

@article{Tsai1996InductionOC,
  title={Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.},
  author={Judy Tsai and Hui Wang and Mark A. Perrella and Masanori Yoshizumi and Nicholas E. S. Sibinga and Linda C. Tan and Elran Haber and T H Chang and Richard Schlegel and Margaret E. Lee},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 1},
  pages={146-53}
}
Homocysteine is an important and independent risk factor for arteriosclerosis. We showed previously that homocysteine stimulates vascular smooth muscle cell proliferation, a hallmark of arteriosclerosis. We show here that homocysteine and serum increased DNA synthesis synergistically in both human and rat aortic smooth muscle cells (RASMCs). Treatment of quiescent RASMCs with 1 mM homocysteine or 2% calf serum for 36 h increased cyclin A mRNA levels by 8- and 14-fold, respectively, whereas… CONTINUE READING

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