Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators.

@article{Lehner2001InductionOC,
  title={Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators.},
  author={Martin Dominik Lehner and Siegfried Morath and Kathrin S. Michelsen and R. Randall Schumann and Thomas Hartung},
  journal={Journal of immunology},
  year={2001},
  volume={166 8},
  pages={5161-7}
}
Exposure of macrophages to LPS induces a state of hyporesponsiveness to subsequent stimulation with LPS termed LPS desensitization or tolerance. To date, it is not known whether similar mechanisms of macrophage refractoriness are induced on contact with components of Gram-positive bacteria. In the present study, we demonstrate that pretreatment with highly purified lipoteichoic acid (LTA) results in suppression of cytokine release on restimulation with LTA in vitro and in vivo in both C3H/HeN… CONTINUE READING
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