Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation.

  title={Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation.},
  author={Edmund R Hollis and Pouya Jamshidi and Karin L{\"o}w and Armin Blesch and Mark H Tuszynski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 17},
Several experimental manipulations of the CNS environment successfully elicit regeneration of sensory and bulbospinal motor axons but fail to elicit regeneration of corticospinal axons, suggesting that cell-intrinsic mechanisms limit the regeneration of this critical class of motor neurons. We hypothesized that enhancement of intrinsic neuronal growth mechanisms would enable adult corticospinal motor axon regeneration. Lentiviral vectors were used to overexpress the BDNF receptor trkB in layer… CONTINUE READING
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