Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts.

@article{Zhu2005InductionOC,
  title={Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts.},
  author={Ming Ji Zhu and Chang Deok Kim and Yoo Bin Kwon and Kyung-Chae Kye and Yuan Yao Chen and Woong-Hee Lee and Sangkeun Lee and Jong Soon Lim and Young-Joon Seo and Ki-Beom Suhr and Park Jk and Jeung-Hoon Lee},
  journal={Experimental dermatology},
  year={2005},
  volume={14 7},
  pages={
          509-14
        }
}
Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid metabolite that can enhance wound healing. In an effort to find downstream effectors of SPC, we performed microarray analysis and found that the expression of the gene for connective tissue growth factor (CTGF) was significantly affected in human skin fibroblasts cultured in vitro. Northern blot analysis showed that SPC markedly induced CTGF mRNA expression in a dose- and time-dependent manner. Consistent with this result, Western… CONTINUE READING