Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts.

  title={Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts.},
  author={Bryan A. Moore and Sadie Aznavoorian and Jeffrey A. Engler and L. Jack Windsor},
  journal={Biochimica et biophysica acta},
  volume={1502 2},
There is a growing body of evidence that implicates matrix metalloproteinases (MMPs) as major players in numerous diseased conditions. The articular cartilage degradation that is characteristic of rheumatoid arthritis (RA) is believed to be mediated by the collagenase subfamily of matrix metalloproteinases. The preference of collagenase-3 (CL-3) for collagen type II makes it a likely candidate in the turnover of articular cartilage and a potential target for drug development. In this study, RA… CONTINUE READING


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