Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells.

@article{Zhong2010InductionOC,
  title={Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells.},
  author={Bin Zhong and David A. Sallman and Danielle L. Gilvary and Daniele Pernazza and Eva Sahakian and Dillon Fritz and Jin Quan Cheng and Ioannis P Trougakos and Sheng Wei and Julie Y. Djeu},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 6},
  pages={1831-41}
}
Clusterin (CLU), in its cytoplasmic form, is abundant in many advanced cancers and has been established to be cytoprotective against chemotherapeutic agents including docetaxel. However, little is known of the mechanism of its induction. Here, we provide evidence that AKT plays a critical role in upregulating cytoplasmic/secretory sCLU, which is responsible for docetaxel resistance. Western blot analysis indicated that docetaxel-resistant sublines derived from DU145 and PC3 prostate tumor cell… CONTINUE READING

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