Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.

@article{Mima2005InductionOC,
  title={Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.},
  author={Shinji Mima and Shinji Tsutsumi and Hironori Ushijima and Miho Takeda and Ikue Fukuda and Kazumi Yokomizo and Keitarou Suzuki and Kuniaki Sano and Tohru Nakanishi and Wataru Tomisato and Tomofusa Tsuchiya and Tohru Mizushima},
  journal={Cancer research},
  year={2005},
  volume={65 5},
  pages={1868-76}
}
Nonsteroidal anti-inflammatory drugs (NSAID) have shown chemopreventive effects in both preclinical and clinical studies; however, the precise molecular mechanism governing this response remains unclear. We used DNA microarray techniques to search for genes whose expression is induced by the NSAID indomethacin in human gastric carcinoma (AGS) cells. Among identified genes, we focused on those related to tight junction function (claudin-4, claudin-1, and occludin), particularly claudin-4… CONTINUE READING

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