Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.

@article{Daley1990InductionOC,
  title={Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.},
  author={George Q. Daley and Richard A. Van Etten and David Baltimore},
  journal={Science},
  year={1990},
  volume={247 4944},
  pages={824-30}
}
In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210bcr/abl protein. The protein-tyrosine kinase activity and hybrid structure of P210bcr/abl are similar to the oncogene product of the Abelson murine leukemia virus, P160gag/v-abl, which induces acute lymphomas. To determine whether P210bcr/abl can induce chronic myelogenous leukemia, murine bone marrow was infected with a… CONTINUE READING
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