Induction of chronic colitis in IL-10 deficient mice requires IL-4.

@article{Specht2006InductionOC,
  title={Induction of chronic colitis in IL-10 deficient mice requires IL-4.},
  author={Sabine Specht and Sandra Arriens and Achim Hoerauf},
  journal={Microbes and infection},
  year={2006},
  volume={8 3},
  pages={694-703}
}
Th 1 cells activated by IL-12 and secreting IFN-gamma have been described as the main mediators for onset and maintenance of chronic colitis in IL-10 deficient mice. It was therefore surprising that mice deficient for IL-4 in addition to IL-10 showed intestinal pathology very rarely, whereas IL-10 KO mice developed rectal prolapse in most cases. To… CONTINUE READING