Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.

@article{Nye1996InductionOC,
  title={Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.},
  author={Heather E Nye and Eric J Nestler},
  journal={Molecular pharmacology},
  year={1996},
  volume={49 4},
  pages={636-45}
}
Previous studies have shown that repeated exposure to cocaine or to several other stimuli induces novel 35-37 kDa Fos-related antigens (chronic Fras) in specific brain regions. Induction of these proteins is associated with prolonged increases in AP-1 DNA binding activity that parallel the long half-life of the chronic Fras in brain. In the current study, we characterized regulation of the chronic Fras in response to prolonged exposure to morphine. After 5 days of morphine treatment, we… CONTINUE READING
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