Induction of chromosome aberrations in peripheral blood lymphocytes after short time inhalation of nitric oxide.

@article{Luhr1998InductionOC,
  title={Induction of chromosome aberrations in peripheral blood lymphocytes after short time inhalation of nitric oxide.},
  author={O. R. Luhr and Claes G. Frostell and Richard Heywood and Sue Riley and Per-Arne L{\"o}nnqvist},
  journal={Mutation research},
  year={1998},
  volume={414 1-3},
  pages={107-15}
}
INTRODUCTION inhalation of nitric oxide (INO) leads to vasodilation of pulmonary vasculature in ventilated regions of the lung. The clinical use of INO, although not formally approved as a drug, is widespread. NO may rapidly form nitrogen dioxide (NO2) in an oxygen containing gas mixture. NO2 has been shown to induce chromosome aberrations and mutations in both animal and bacterial test systems. We investigated whether a 2-h exposure to NO would increase frequencies of cells with chromosome… CONTINUE READING