Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

@article{Eisele2009InductionOC,
  title={Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.},
  author={Yvonne S. Eisele and Tristan Bolmont and Mathias Heikenwalder and Franziska Langer and Laura Helen Jacobson and Zheng-Xin Yan and Klaus F. Roth and Adriano Aguzzi and Matthias Staufenbiel and Lary C Walker and Mathias Jucker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={12926-31}
}
Despite the importance of the aberrant polymerization of Abeta in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of Abeta aggregation in vivo. Here we show that induction of cerebral beta-amyloidosis can be achieved in many different brain areas of APP23 transgenic mice through the injection of dilute Abeta-containing brain extracts. Once the amyloidogenic process has been exogenously induced, the nature of the induced Abeta-deposition is determined by… CONTINUE READING

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