Induction of cellular resistance against Kupffer cell-derived oxidant stress: a novel concept of hepatoprotection by ischemic preconditioning.

@article{Schauer2003InductionOC,
  title={Induction of cellular resistance against Kupffer cell-derived oxidant stress: a novel concept of hepatoprotection by ischemic preconditioning.},
  author={Rolf Josef Schauer and Alexander L Gerbes and Daniel Vonier and Mark op den Winkel and Peter Fraunberger and Manfred Bilzer},
  journal={Hepatology},
  year={2003},
  volume={37 2},
  pages={286-95}
}
Ischemic preconditioning (IP) triggers protection of the liver from prolonged subsequent ischemia. However, the underlying protective mechanisms are largely unknown. We investigated whether and how IP protects the liver against reperfusion injury caused by Kupffer cell (KC)-derived oxidants. IP before 90 minutes of warm ischemia of rat livers in vivo significantly reduced serum alanine aminotransferase (AST) levels and leukocyte adherence to sinusoids and postsinusoidal venules during… CONTINUE READING

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