Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.

  title={Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.},
  author={Gianluigi Giannelli and J Falk-Marzillier and Oronzo Schiraldi and William G Stetler-Stevenson and Vito Quaranta},
  volume={277 5323},
Structural changes in the extracellular matrix are necessary for cell migration during tissue remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease-2 (MMP2) was shown to induce migration of breast epithelial cells. MMP2 cleaved the Ln-5 gamma2 subunit at residue 587, exposing a putative cryptic promigratory site on Ln-5 that triggers cell motility. This altered form of Ln-5 is found in tumors and in tissues undergoing remodeling, but not in quiescent… CONTINUE READING
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