Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.

@article{Lim2007InductionOC,
  title={Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.},
  author={Do Young Lim and Yoonhwa Jeong and Angela L. Tyner and Jung Han Yoon Park},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={292 1},
  pages={
          G66-75
        }
}
  • D. LimY. Jeong J. Park
  • Published 2007
  • Biology, Chemistry
  • American journal of physiology. Gastrointestinal and liver physiology
Luteolin is 3',4',5,7-tetrahydroxyflavone found in celery, green pepper, and perilla leaf that inhibits tumorigenesis in animal models. We examined luteolin-mediated regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line. Luteolin decreased DNA synthesis and viable HT-29 cell numbers in a concentration-dependent manner. It inhibited cyclin-dependent kinase (CDK)4 and CDK2 activity, resulting in G1 arrest with a concomitant decrease of phosphorylation of… 
View on PubMed
ajpgi.physiology.org
169 Citations
Highly Influential Citations
6
Background Citations
62
Methods Citations
4
Results Citations
5

Figures from this paper

169 Citations

Modulation of G2/M cell cycle arrest and apoptosis by luteolin in human colon cancer cells and xenografts

The evidence suggests that luteolin may be a potential chemopreventive and chemotherapeutic agent against human colon cancer.

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway.

Luteolin induced-growth inhibition and apoptosis of human esophageal squamous carcinoma cell line Eca109 cells in vitro.

Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose- and time-dependent manner and induced apoptosis of Eca109 cells, in line with the fact that luteolin was able to inhibit Eca 109 cell proliferation.

Luteolin induced G 2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells

Luteolin displayed a significant cytotoxic effect through cell cycle arrest and apoptosis induction in A549 cells, suggesting that luteolin might have therapeutic potential against NSCLC.

Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells.

  • Xueting CaiTingmei Ye P. Cao
  • Biology, Chemistry
    Toxicology in vitro : an international journal published in association with BIBRA
  • 2011

Induction of G 1 and G 2 / M cell cycle arrests by the dietary compound 3 , 3 '-diindolylmethane in HT-29 human colon cancer cells

It is demonstrated that DIM induces G1 and G2/M phase cell cycle arrest in HT-29 cells, and this effect may be mediated by reduced CDK activity.

Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells

It is demonstrated that DIM induces G1 and G2/M phase cell cycle arrest in HT-29 cells, and this effect may be mediated by reduced CDK activity.

Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450

The results suggest that luteolin can induce cell apoptosis and cell cycle arrest in G2/M phase through mitochondrial pathway in EC1 and KYSE450 cell lines and proper utilization of lutenolin might be a practical approach in ESCC chemotherapy.

Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway

It is shown that luteolin inhibits the growth of HCT116 colon cancer cells through p53-dependent regulation of apoptosis and cell cycle arrest regardless of the induction of autophagy.

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Findings reveal that the anti-proliferative activity of diosgenin involves the induction of G2/M phase arrest via modulating the Cdc25C-Cdc2-cyclin B pathway and mitochondria-mediated apoptosis in human breast cancer cell lines, which suggests the potential usefulness of diOSgenin in treating breast cancer.
...

43 References

Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.

Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1

Our previous studies indicated that dietary conjugated linoleic acid (CLA) inhibits colon tumor cell proliferation in vitro and in vivo. To identify mechanisms by which CLA regulates growth arrest,…

Individual and Interactive Effects of Apigenin Analogs on G2/M Cell-Cycle Arrest in Human Colon Carcinoma Cell Lines

The induction of cell-cycle arrest by five of seven tested apigenin analogs and the additive induction by the combination of flavonoids at low doses suggest that apigen in-related flavonoid may cooperatively protect against colorectal cancer through conjoint blocking of cell -cycle progression.

Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids.

In this study, we have investigated the underlying molecular mechanism for the potent proapoptotic effect of luteolin on human hepatoma cells both in vitro and in vivo, focusing on the signal…

Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells

It is shown for the first time that the apoptosis by luteolin is mediated through death receptor 5 (DR5) upregulation, and the possibility that treatment with luteolini might be promising as a new therapy against cancer is raised.

Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line.

  • H. ChoW. Kim J. Park
  • Biology
    American journal of physiology. Gastrointestinal and liver physiology
  • 2003
It is demonstrated that CLA inhibits cell proliferation and stimulates apoptosis in HT-29 cells and that this may be mediated by its ability to downregulate ErbB3 signaling and the PI3-kinase/Akt pathway.

Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

Pretreatment with luteolin greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells, and reveals a novel function of lutingolin and enhances the value of lUTEolin as an anticancer agent.

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

The role of p21 in regulating cell death and the potential relevance of its expression in cancer are discussed and this may counteract its tumor-suppressive functions as a growth inhibitor.

Luteolin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells

A novel function of luteolin is revealed and the value of lutingolin as an anticancer agent is enhanced, suggesting that NF-κB and JNK are closely associated with the sensitization effect of lUTEolin.

Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells.

The results indicate that the blockade of the EGFR-signaling pathway by the PTK inhibitors Qu and Lu significantly inhibits the growth of MiaPaCa-2 cells and induces apoptosis.