Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.

@article{Kikukawa2008InductionOC,
  title={Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.},
  author={Yoshitaka Kikukawa and Yutaka Okuno and Hiro Tatetsu and Miki Nakamura and Naoko Harada and Shikiko Ueno and Y. Kamizaki and Hiroaki Mitsuya and Hiroyuki Hata},
  journal={International journal of oncology},
  year={2008},
  volume={33 4},
  pages={
          807-14
        }
}
Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania Cepharantha Hayata, has been used in Japan for treating patients with radiation-induced leucopenia or thrombocytopenia. We treated a patient with multiple myeloma (MM), who was not responding to preceding chemotherapy, who coincidently received therapy with CEP due to thrombocytopenia. Since the case showed a marked reduction of tumor load, direct anti-tumor effects of CEP to myeloma cells were investigated in vitro. Anti… Expand
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Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells
  • Zan Chen, C. Huang, +4 authors Ming Xu
  • Biology, Medicine
  • Acta Pharmacologica Sinica
  • 2012
TLDR
Findings suggest that inhibition of STAT3 signaling pathway is involved in the anti-tumor activity of CEP. Expand
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Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF‐κB
TLDR
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TLDR
The experimental results suggest that cepharanthin can induce apoptosis both in P388/S and P 388/DOX cells, especially in the latter, and may be implicated in the production of reactive oxygen species and Fas-antigen expression in tumor cells. Expand
Effects of Combination Chemotherapy with Biscoclaurine-derived Alkaloid (Cepharanthine) and Nimustine Hydrochloride on Malignant Glioma Cell Lines
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In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation, and in combination with ACNU, the effects of the higher concentrations of CEP were enhanced and the cascade of apoptosis two possible cascades are in play. Expand
Characteristics of antitumour activity of cepharanthin against a human adenosquamous cell carcinoma cell line.
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Findings suggest that cepharanthin induces G1 arrest via expression of p21(WAF1) and apoptosis through caspase 3 and this results in a significant suppression of tumour growth and an induction of apoptosis. Expand
Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines
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The results suggest that CEP, which does not have bone marrow toxicity, may possess therapeutic potential against human leukemias, including CML, which is resistant to anticancer drugs and radiotherapy. Expand
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TLDR
Results indicate that cepharanthine may inhibit the growth of human oral SCC cells by down-regulating cyclin E to induce G1 arrest through a pathway of p27Kip1 induction. Expand
Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR.
TLDR
Time-lapse microscopic observation revealed that ADR dominantly induced apoptosis much more than necrosis for both parent and resistant cells, and that the use of 0.5 micro g/ml CEP with ADR synergistically accelerated apoptosis in resistant cells was clarified. Expand
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TLDR
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TLDR
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TLDR
The data suggest that co-administration of CEP with DOX may potentiate the effect of chemotherapy on drug-resistant HCC, supporting the use of P-gp modulation as a new chemotherapeutic approach. Expand
Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells
TLDR
Cepharanthine enhanced sensitivity to doxorubicin (ADM) and vincristine (VCR), and enhanced apoptosis induced by ADM and VCR of P‐gp negative K562 cells, and should be useful for treating patients with tumors. Expand
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