Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA.

@article{Cho2006InductionOC,
  title={Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA.},
  author={Nam Hoon Cho and Yoon Pyo Choi and Dong Suk Moon and Haeryoung Kim and Suki Hee Kang and Owen Ding and Sun Young Rha and Yeon Ju Yang and Sang Ho Cho},
  journal={Cancer science},
  year={2006},
  volume={97 10},
  pages={1082-92}
}
Cyclin A1 and cyclin B1 are overexpressed in various tumors but are present at low levels in normal tissues. Cyclin A1 is restricted to germ cells undergoing meiosis. In order to explore the possibility of using cyclin A1 and cyclin B1 as anticancer targets, we knocked them down in two lung cancer cell lines, H157 and H596, using siRNA. As with cyclin A1 siRNA in lung cancer cell lines, cyclin B1, Cdc2 and CDK2 were all significantly downregulated. The S phase fraction increased significantly… CONTINUE READING

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