Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells.

@article{Jeon2011InductionOC,
  title={Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells.},
  author={Hwang Gyun Jeon and Cheol Yong Yoon and Ji Hyeong Yu and Mi Jeong Park and Jung Eun Lee and Seong Jin Jeong and Sung Kyu Hong and S Byun and Sang Eun Lee},
  journal={The Journal of urology},
  year={2011},
  volume={186 5},
  pages={2084-93}
}
PURPOSE Previously we reported that the histone deacetylase inhibitor trichostatin A (Sigma®) synergistically potentiates the antitumor effects of cisplatin in human bladder cancer cells. In the current study we explored the synergistic interaction between trichostatin A and gemcitabine (Novartis Korea, Seoul, Korea), the other mainstay chemotherapeutic regimen for advanced bladder cancer. MATERIALS AND METHODS The bladder cancer cell lines HTB5, HTB9, T24, J82, UMUC14 and SW1710 (ATCC®) were… CONTINUE READING
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