Induction of cardiac fibrosis by angiotensin II.

@article{Lijnen2000InductionOC,
  title={Induction of cardiac fibrosis by angiotensin II.},
  author={Paul J. Lijnen and Victor V. Petrov and Robert H. Fagard},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2000},
  volume={22 10},
  pages={
          709-23
        }
}
The possible contributions of the angiotensin receptor subtypes 1 (AT1) and 2 (AT2) to angiotensin II-induced changes in collagen secretion and production were studied using the specific angiotensin receptor AT1 and AT2 antagonists telmisartan and P-186. The role of the renin-angiotensin system and its interaction with transforming growth factor-beta 1 (TGF-beta 1) in collagen deposition in cardiac fibroblasts in relation to the development of myocardial fibrosis is also discussed. Cardiac… CONTINUE READING

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