Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry.

@article{CunhaNeto2006InductionOC,
  title={Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry.},
  author={Edecio Cunha-Neto and Angelina M. Bilate and Kenneth V Hyland and Simone Gonçalves Fonseca and Jorge Agle Kalil and David M. Engman},
  journal={Autoimmunity},
  year={2006},
  volume={39 1},
  pages={41-54}
}
Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy (CCC) up to 30 years after infection. Cardiomyocyte destruction is associated with a T cell-rich inflammatory infiltrate and fibrosis. The presence of such lesions in the relative scarcity of parasites in the heart, suggested that CCC might be due, in part, to a postinfectious autoimmune process. Over the last two decades… CONTINUE READING
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