Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation.

@article{Madariaga2013InductionOC,
  title={Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation.},
  author={Maria Lucia L. Madariaga and S G Michel and Masayuki Tasaki and Vincenzo Villani and Glenn M La Muraglia and Smita Sihag and James D Gottschall and Evan A. Farkash and Akira Shimizu and James S. Allan and David H Sachs and Kazuhiko Yamada and Joren C. Madsen},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2013},
  volume={13 10},
  pages={
          2558-66
        }
}
We have previously shown that tolerance of kidney allografts across a full major histocompatibility complex (MHC) barrier can be induced in miniature swine by a 12-day course of high-dose tacrolimus. However, that treatment did not prolong survival of heart allografts across the same barrier. We have now tested the effect of cotransplanting an allogeneic heart and kidney from the same MHC-mismatched donor using the same treatment regimen. Heart allografts (n = 3) or heart plus kidney allografts… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Similar Papers

Loading similar papers…