Induction of cancer cell-specific death via MMP2 promoterdependent Bax expression.

@article{Seo2009InductionOC,
  title={Induction of cancer cell-specific death via MMP2 promoterdependent Bax expression.},
  author={Eunjeong Seo and Sewoon Kim and Eek-Hoon Jho},
  journal={BMB reports},
  year={2009},
  volume={42 4},
  pages={217-22}
}
Controlled gene expression in specific cells is a valuable tool for gene therapy. We attempted to determine whether the lentivirus-mediated Tet-On inducible system could be applied to cancer gene therapy. In order to select the genes that induce cancer cell death, we compared the ability of the known pro-apoptotreic genes, Bax and tBid, and a cell cycle inhibitor, p21cip1/waf1, and determined that Bax was the most effective. For the cancer cell-specific expression of rtTA2(S)-M2, we tested the… CONTINUE READING

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