Induction of cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) expression in rat brain by uncompetitive N-methyl-D-aspartate receptor antagonists.

@article{Storvik2000InductionOC,
  title={Induction of cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) expression in rat brain by uncompetitive N-methyl-D-aspartate receptor antagonists.},
  author={Markus Storvik and Alexander M. van der Linden and Outi Kontkanen and Merja Lakso and Eero Castr{\'e}n and Garry Wong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 1},
  pages={52-60}
}
The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor mediates fast excitatory neurotransmission, and agents that attenuate this function are neuroprotective, anesthetic, and psychotropic. To determine whether cAMP regulatable transcription factors play a role in the neurochemical actions of agents acting through NMDA receptors, the effects of the acute administration of uncompetitive and competitive antagonists on the expression of cAMP response element modulator (CREM) and inducible… CONTINUE READING