Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.

@article{Singewald2003InductionOC,
  title={Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.},
  author={Nicolas Singewald and Peter Salchner and Trevor Sharp},
  journal={Biological psychiatry},
  year={2003},
  volume={53 4},
  pages={275-83}
}
BACKGROUND The fact that induction of anxiety- and panic-related symptoms is a property common to a range of drugs suggests that common neural substrates underlie their behavioral effects. METHODS We used Fos immunocytochemistry to test the effects of four anxiogenic drugs (FG-7142, yohimbine, m-chlorophenylpiperazine [mCPP], and caffeine) on anxiety-related circuitry in rat forebrain. RESULTS All four drugs commonly increased Fos-like immunoreactivity in 7 of 41 brain areas investigated… CONTINUE READING
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