Induction of bystander T cell proliferation by viruses and type I interferon in vivo.

@article{Tough1996InductionOB,
  title={Induction of bystander T cell proliferation by viruses and type I interferon in vivo.},
  author={David F. Tough and Persephone Borrow and Jonathan Sprent},
  journal={Science},
  year={1996},
  volume={272 5270},
  pages={1947-50}
}
T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various environmental antigens. However, the massive proliferation of T cells seen in viral infections is suggestive of a bystander reaction driven by cytokines instead of the TCR. In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of… CONTINUE READING
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