Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

@article{EstradaBernal2012InductionOB,
  title={Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.},
  author={Adriana Estrada-Bernal and Kamalakannan Palanichamy and Abhik Ray Chaudhury and James R. Van Brocklyn},
  journal={Neuro-oncology},
  year={2012},
  volume={14 4},
  pages={
          405-15
        }
}
FTY720 is a sphingosine analogue that down regulates expression of sphingosine-1-phosphate receptors and causes apoptosis of multiple tumor cell types, including glioma cells. This study examined the effect of FTY720 on brain tumor stem cells (BTSCs) derived from human glioblastoma (GBM) tissue. FTY720 treatment of BTSCs led to rapid inactivation of ERK MAP kinase, leading to upregulation of the BH3-only protein Bim and apoptosis. In combination with temozolomide (TMZ), the current standard… CONTINUE READING
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