Induction of bone formation by activated monocytes / macrophages depends on Oncostatin M signaling

@inproceedings{Guihard2012InductionOB,
  title={Induction of bone formation by activated monocytes / macrophages depends on Oncostatin M signaling},
  author={Pierre Guihard and Yannic Danger and B{\'e}n{\'e}dicte Brounais and Emmanuelle David and R{\'e}gis Brion and Jo{\"e}l Del{\'e}crin and Carl D Richards and Sylvie Chevalier and Françoise R{\'e}din{\'i} and Dominique Heymann and Hugues Gascan and Fr{\'e}d{\'e}ric Blanchard},
  year={2012}
}
Bone resorption by osteoclasts and bone formation by osteoblasts are tightly coupled processes implicating factors in TNF, bone morphogenetic protein and Wnt families. In osteoimmunology, macrophages were described as another critical cell population regulating bone formation by osteoblasts but the coupling factors were not identified. Using a high throughput approach, we identified here Oncostatin M (OSM), a cytokine of the IL-6 family, as a major coupling factor produced by activated… CONTINUE READING