Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.

@article{Spiegelman2001InductionOB,
  title={Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.},
  author={Vladimir S. Spiegelman and Pete Stavropoulos and Esther Latres and Michele Pagano and Ze'ev A Ronai and Thomas J. Slaga and Serge Yu. Fuchs},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 29},
  pages={27152-8}
}
Activation of Jun N-kinase (JNK) and NF-kappaB transcription factor are the hallmarks of cellular response to stress. Phosphorylation of NF-kappaB inhibitor (IkappaB) by respective stress-inducible kinases (IKK) is a key event in NF-kappaB activation. beta-TrCP F-box protein mediates ubiquitination of phosphorylated IkappaB via recruitment of SCF(beta-TrCP)-Roc1 E3 ubiquitin ligase complex. Subsequent proteasome-dependent degradation of IkappaB results in activation of the NF-kappaB pathway. We… CONTINUE READING

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