Induction of bacterial antigen-specific colitis by a simplified human microbiota consortium in gnotobiotic interleukin-10-/- mice.

@article{Eun2014InductionOB,
  title={Induction of bacterial antigen-specific colitis by a simplified human microbiota consortium in gnotobiotic interleukin-10-/- mice.},
  author={Chang Soo Eun and Yoshiyuki Mishima and Steffen Wohlgemuth and Bo Liu and Maureen A. Bower and Ian M. Carroll and Ryan Balfour Sartor},
  journal={Infection and immunity},
  year={2014},
  volume={82 6},
  pages={2239-46}
}
We evaluated whether a simplified human microbiota consortium (SIHUMI) induces colitis in germfree (GF) 129S6/SvEv (129) and C57BL/6 (B6) interleukin-10-deficient (IL-10(-/-)) mice, determined mouse strain effects on colitis and the microbiota, examined the effects of inflammation on relative bacterial composition, and identified immunodominant bacterial species in "humanized" IL-10(-/-) mice. GF wild-type (WT) and IL-10(-/-) 129 and B6 mice were colonized with 7 human-derived inflammatory… CONTINUE READING