Induction of autophagy in axonal dystrophy and degeneration.

@article{Wang2006InductionOA,
  title={Induction of autophagy in axonal dystrophy and degeneration.},
  author={Qing Wang and Yaomei Ding and D. Stave Kohtz and Noboru Mizushima and Ileana M. Cristea and Michael P. Rout and Brian T Chait and Yun Ying Susan Zhong and Nathaniel Heintz and Zhenyu Yue},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 31},
  pages={
          8057-68
        }
}
Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic contents. It has been implicated in a variety of physiological and pathological conditions relevant to neurological diseases. However, the regulation of autophagy in neurons and its role in neuronal and axonal pathology are not yet understood. Using transgenic mice producing green fluorescent protein-tagged autophagic marker microtubule-associated protein light chain 3 (GFP-LC3), we provide molecular… CONTINUE READING

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