Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth.

@article{Chen2013InductionOA,
  title={Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth.},
  author={Jia-Xiang Chen and Ying-jian Sun and Pan Wang and Ding-xin Long and Wei Li and Li Li and Yi-Jun Wu},
  journal={Toxicology},
  year={2013},
  volume={310},
  pages={
          92-7
        }
}
Tri-ortho-cresyl phosphate (TOCP), an organophosphorus ester, can cause neurotoxicity such as organophosphorus ester-induced delayed neuropathy (OPIDN) in humans and sensitive animals. Moreover, it also affects the development of central nervous system and differentiation of neuronal cells. In this study, retinoic acid-induced differentiated human neuroblastoma SH-SY5Y cells are utilized to investigate the effects of TOCP on neurite outgrowth and the underlying mechanisms. We found that low… CONTINUE READING
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