Induction of autophagy and inhibition of tumorigenesis by beclin 1

@article{Liang1999InductionOA,
  title={Induction of autophagy and inhibition of tumorigenesis by beclin 1},
  author={Xiao Huan Liang and S. Jackson and Matthew N.J. Seaman and Kristy R. Brown and Bettina Kempkes and Hanina Hibshoosh and Beth Levine},
  journal={Nature},
  year={1999},
  volume={402},
  pages={672-676}
}
The process of autophagy, or bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important in normal growth control and may be defective in tumour cells. However, little is known about the genetic mediators of autophagy in mammalian cells or their role in tumour development. The mammalian gene encoding Beclin 1 (ref. 3), a novel Bcl-2-interacting, coiled-coil protein, has structural similarity to the yeast autophagy gene, apg6/vps30 (refs 4, 5), and is mono… 
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.
TLDR
It is reported that inhibition of autophagy by FIP200 ablation suppresses mammary tumor initiation and progression in a mouse model of breast cancer driven by the PyMT oncogene, and FIP 200 is suggested as a potential target for cancer therapy.
Role of Autophagy in Breast Cancer
TLDR
It is found that allelic loss of beclin1 renders immortalized mouse mammary epithelial cells susceptible to metabolic stress and accelerates lumen formation in mammary acini, and loss of the prosurvival role of autophagy likely contributes to breast cancer progression by promoting genome damage and instability.
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.
TLDR
It is shown that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions, providing genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression.
Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor ReceptorSignaling: A Dissertation
TLDR
A novel role for Beclin 1 in regulating growth factor signaling is identified and a mechanism by which loss of BeClin 1 expression would enhance breast cancer progression independent of its impact on autophagy is revealed.
Autophagic processes of normal and malignant metabolic pathways
TLDR
Optimal combination of inductors or inhibitors of autophagy with chemo or radiotherapy in a variety of tumor type, in different phases, can be successful approaches for improve the effect of anticancer therapies.
p53-Mediated Molecular Control of Autophagy in Tumor Cells
TLDR
This review focuses on p53 signaling as a mediator of the autophagic pathway in tumor cells as p53 deficiency or mutant variants of p53 that accumulate in the cytoplasm of tumor cells enable activation of autophagy.
Promoting Tumorigenesis by Suppressing Autophagy
TLDR
A connection between Beclin 1 and the Akt signaling pathway is established, which controls a large spectrum of cellular functions associated with cancer ranging from cell proliferation and survival to angiogenesis and metabolism, and underscores the importance of autophagy in tumor suppression.
Downregulation of Beclin1 and Impairment of Autophagy in a Small Population of Colorectal Cancer
TLDR
Investigation of the role autophagy plays in colorectal cancers with downregulaion of Beclin 1 showed that LC3 was suppressed in the coloreCTal cancers (9.86 %) with downregulation of BeClin 1.
Anti- and pro-tumor functions of autophagy.
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
TLDR
It is shown that Beclin-1 knockdown, but not Atg5 deletion in a murine CML model leads to a reduced leukemic burden and results in a significantly prolonged median survival of targeted mice.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.
TLDR
Reduced autophagy was observed in peritumorous hepatocytes and in cells from preneoplastic liver, and a complete suppression of autophagic protein degradation was seen in normal hepatocytes treated with ascitic fluid from an ascites hepatoma, suggesting that tumour cells and their precursors may produce autophile-suppressive factors with an autocrine and paracrine action.
Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*)
TLDR
The fluxes through the autophagic and protein synthetic pathways are regulated in an opposite manner by the degree to which S6 is phosphorylated, which concludes that inhibition of autophagy and phosphorylation of S6 are under the same signal transduction pathway.
Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.
TLDR
Results indicate that deregulated expression of the cyclin D1 gene can cause disturbances in cell cycle control and gene expression and also enhance tumorigenesis.
Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
  • P. Seglen, P. B. Gordon
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1982
TLDR
The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy.
Growth retardation and tumour inhibition by BRCA1
TLDR
It is shown that retroviral transfer of the wild-type BRCA1 gene inhibits growth in vitro of all breast and ovarian cancer cell lines tested, but not colon or lung cancer cells or fibroblasts.
Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein
TLDR
It is demonstrated that Beclin is a novel Bcl-2-interacting cellular protein that may play a role in antiviral host defense.
...
1
2
3
4
...