Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells.

@article{Ishikawa2009InductionOA,
  title={Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells.},
  author={Hideaki Muroishi Ishikawa and Kozue Takeda and Akira Okamoto and Sei-ichi Matsuo and Ken-ichi Isobe},
  journal={The Journal of investigative dermatology},
  year={2009},
  volume={129 7},
  pages={1688-95}
}
Systemic sclerosis (SSc) is an autoimmune disease characterized by the excessive deposition of collagen in the skin or other organs and the production of specific antinuclear antibodies (ANAs). Recently, bleomycin (BLM)-induced experimental scleroderma was reported in a murine model. Here, we present further development of this model and suggest that it is appropriate for the analysis of human diffuse type SSc. BLM was injected into the shaved backs of C3H or BALB/c mice (100 microg/mouse) 5… CONTINUE READING

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