Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.

@article{Tai2007InductionOA,
  title={Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.},
  author={Xuguang Tai and François van Laethem and Arlene H Sharpe and Alfred Singer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 34},
  pages={13756-61}
}
CTLA-4-deficient mice develop a lethal autoimmune lymphoproliferative disorder that is strictly dependent on in vivo CD28 costimulation. Nevertheless, it is not known whether there is a specific site on the CD28 molecule that is required for induction of autoimmunity. Using CTLA-4-deficient mice expressing CD28 molecules with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo costimulation for induction of autoimmune disease strictly requires an intact… CONTINUE READING

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