Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters.

@article{Wang1994InductionOA,
  title={Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters.},
  author={Jun Wang and S Q Chen},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1218 1},
  pages={48-54}
}
The expression of aromatase in JAR cells, human placental choriocarcinoma cells, was found to be induced by the treatment of phorbol 12,13-diacetate (PDA), phorbol 12,13-didecanoate (PDD), or phorbol 12-myristate 13-acetate (TPA), but not 4 alpha-phorbol, 12,13-didecanoate (4 alpha PDD). At 1 microM or higher concentrations, these phorbol esters increased the level of aromatase mRNA and aromatase activity in a dose- and time-dependent fashion. Since the rates of the decrease of aromatase mRNA… CONTINUE READING