Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells.

@article{Kusuhara1998InductionOA,
  title={Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells.},
  author={Hirohisa Kusuhara and Hirofumi Matsuyuki and Minoru Matsuura and T.. Imayoshi and Tadayuki Okumoto and Hidetaka Matsui},
  journal={European journal of pharmacology},
  year={1998},
  volume={360 2-3},
  pages={273-80}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to cause apoptosis in several cell lines including transformed chicken embryo fibroblasts and human colon cancer cells. We herein report the apoptotic effect of NSAIDs in a non-transformed cell line derived from the rat gastric mucosa, RGMI (rat gastric mucosa cell first). 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid (indomethacin) and sodium 2-(2,6-dichloroanilino)phenylacetate (sodium diclofenac), potent and non… CONTINUE READING