Induction of apoptosis using 2′,2′difluorodeoxycytidine (gemcitabine) in combination with antimetabolites or anthracyclines on malignant lymphatic and myeloid cells. Antagonism or synergism depends on incubation schedule and origin of neoplastic cells

@article{Chow2000InductionOA,
  title={Induction of apoptosis using 2′,2′difluorodeoxycytidine (gemcitabine) in combination with antimetabolites or anthracyclines on malignant lymphatic and myeloid cells. Antagonism or synergism depends on incubation schedule and origin of neoplastic cells},
  author={Kai Uwe Chow and J Scott Ries and Eckhart Weidmann and F. Pourebrahim and Simone Napieralski and Manuela Stieler and Simone Boehrer and Mathias Johannes Rummel and Janet R. Stein and Dieter Hoelzer and Paris Sophokles Mitrou},
  journal={Annals of Hematology},
  year={2000},
  volume={79},
  pages={485-492}
}
 Induction of apoptosis in vitro using gemcitabine (dFdC) in combination with cladribine (2-CdA) and other cytotoxic drugs on malignant mononuclear cells (MNCs) of patients with acute myeloid leukemia (AML, n=20) and chronic lymphocytic leukemia (CLL, n=20) in myeloid (HL60, HEL) and lymphatic cell lines (HUT78, JURKAT) was investigated using different… CONTINUE READING