Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.

@article{Aryapour2012InductionOA,
  title={Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.},
  author={Hassan Aryapour and Gholamhossein Riazi and Shahin Ahmadian and Alireza Foroumadi and M Mahdavi and Saeed Emami},
  journal={Pharmaceutical biology},
  year={2012},
  volume={50 12},
  pages={1551-60}
}
CONTEXT As microtubules are highly involved in cellular growth, it appears to be a preferential target for cancer treatment. Therefore, many efforts have been performed to discover drugs that affect on microtubule function. Several microtubule inhibitors are in various stages of laboratory evaluations and clinical trials. OBJECTIVE A series of chromene-based chalcones with chlorine, methoxy, fluorine, tetrahydropyranyloxy and cyanide substituents were prepared and evaluated for cytotoxic… CONTINUE READING
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