Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant.

@article{Azuma2000InductionOA,
  title={Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant.},
  author={Tetsushi Azuma and Naohide Watanabe and Hitoshi Yagisawa and Hajime Hirata and Michiko Iwamura and Yoshinori Kobayashi},
  journal={Immunopharmacology},
  year={2000},
  volume={46 1},
  pages={29-37}
}
Two types of immunosuppressants, cycloprodigiosin hydrochloride (cPrG) and L-leucyl-L-leucine methyl ester (LeuLeuOMe), both have the ability to selectively inhibit the lysosomal function, and a related compound to cPrG, prodigiosin 25-C, and LeuLeuOMe have been reported to selectively inhibit the T cell function in vitro. We therefore examined the cell-type specificity of cPrG and LeuLeuOMe using murine splenocytes. Concanavalin A (Con A)- and lentil lectin-induced proliferation was suppressed… CONTINUE READING

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