• Biology, Medicine
  • Published in
    Molecular reproduction and…
    2006
  • DOI:10.1002/mrd.20386

Induction of apoptosis increases SUMO-1 protein expression and conjugation in mouse periovulatory granulosa cells in vitro.

@article{Shao2006InductionOA,
  title={Induction of apoptosis increases SUMO-1 protein expression and conjugation in mouse periovulatory granulosa cells in vitro.},
  author={Ruijin Shao and Emilia Rung and Birgitta Weijdeg{\aa}rd and H{\aa}kan Billig},
  journal={Molecular reproduction and development},
  year={2006},
  volume={73 1},
  pages={
          50-60
        }
}
The small ubiquitin-related modifier-1 (SUMO-1) with broad cellular expression has been implicated in a range of cellular processes, such as cell proliferation, differentiation, and apoptosis. As shown recently, SUMO-1 is expressed and regulated by gonadotropins, in particular an ovulatory hCG stimulus in mouse granulosa cells in vivo. To test the hypothesis that modulation of granulosa cell apoptosis changes SUMO-1 expression during granulosa cell differentiation in the mouse ovary, we… CONTINUE READING

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