Induction of apoptosis in the human promyelocytic leukemia cell line HL60 by falconensone A and its derivatives, new polyenes.

@article{Takahashi2000InductionOA,
  title={Induction of apoptosis in the human promyelocytic leukemia cell line HL60 by falconensone A and its derivatives, new polyenes.},
  author={Noriko Takahashi and Yoshinori Kubo and Akiyo Iwahori and Ken-ichi Kawai and Tetsuya Fukui},
  journal={Biological \& pharmaceutical bulletin},
  year={2000},
  volume={23 6},
  pages={
          748-54
        }
}
Falconensones A and B are a new type of yellow pigment with structural similarity to retinoic acid isolated from the mycelial extract of ascomycetous fungi, Emericella falconensis or Emericella fruticulosa. In the present study we show that falconensone A alone induced apoptosis of HL60 human leukemia cells, while falconensone B, the 4'-nor-methyl derivative of falconensone A, had much lower activity. The synthetic derivatives of falconensone A, falconensone A p-bromophenylhydrazone and… 
Antitumor efficacy in vitro and in vivo of falconensones, a new type of polyene.
TLDR
Results indicate that falconensone A and its derivatives exhibit anticancer efficacy in a broad spectrum of cancer cell lines and may have great potential for clinical use in the treatment of various cancers.
[Induction of cell differentiation and development of new anticancer drugs].
  • N. Takahashi
  • Biology, Chemistry
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2002
TLDR
Screening of differentiation-inducing factors, such as purified aldehyde reductase, a xenobiotic metabolite enzyme, that induces differentiation of human acute myeloid leukemia HL60 cells into monocyte/macrophage cells is described, and mechanisms of all-trans-retinoic acid (RA)-induced differentiation are covered.
Ham-Wasserman lecture: treatment of acute leukemia by inducing differentiation and apoptosis.
  • Zhen-yi Wang
  • Medicine, Biology
    Hematology. American Society of Hematology. Education Program
  • 2003
TLDR
Progress at the molecular level has been achieved in explaining the mechanisms of action of ATRA and arsenic compounds, and several new agents have emerged, although their clinical effectiveness remains to be confirmed.
Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes.
TLDR
Results indicate that RA and 4-HPR in SG-liposomes exhibit anticancer efficacy on metastatic cancers, and may have great potential for clinical use in the treatment of various cancers.
Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities
TLDR
This review presents 236 natural compounds, which were reported from marine and terrestrial Emericella, which imply the need for substantial investigation of alternative activities, including antimicrobial or cytotoxicity.
Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991
TLDR
Structures of 1–14 were elucidated on the basis of spectroscopic analysis and chemical evidence and showed moderate antibacterial activities against Bacillus subtilis.
EFFECT OF CHAIN LENGTH AND ALDEHYDIC FUNCTION ON SOME BIOLOGICAL PROPERTIES OF PARROPOLYENES
Summary Parropolyenes, also called parroenes, parrodienes and psittacofulvines, are aldehydes costituted of an unsaturated chain ranging from 8 to 18 carbon atoms. These compounds have been isolated

References

The Systematic Identification of Organic Compounds:
AbstractINTEREST in organic identification work in the University of Illinois was first aroused by Prof. C. G. Derick- in 1908, and the course was developed by Prof. O. Kamm, whose book on the