Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs.

@article{Samorapoompichit2003InductionOA,
  title={Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs.},
  author={Puchit Samorapoompichit and Marianne Steiner and Trevor Lucas and F. Wachtler and Andreas Schedled and Wolfgang R. Sperr and Peter Valent},
  journal={Leukemia & lymphoma},
  year={2003},
  volume={44 3},
  pages={
          509-15
        }
}
Mast cell leukemia (MCL) is a rare disorder characterized by rapid disease progression, resistance against conventional cytoreductive drugs, and short survival. In an attempt to identify drugs that show significant antiproliferative effects on neoplastic mast cells (MC), we exposed the MCL-derived cell line HMC-1 to various cytotoxic drugs including 2-chlorodeoxyadenosine [2CdA], fludarabine and cytosine arabinoside [ARA-C]. The effects of these drugs on 3H-thymidine incorporation, electron… CONTINUE READING
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