Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide.

@article{Cai1997InductionOA,
  title={Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide.},
  author={Lu Cai and Barbara F. Hales and Bernard Robaire},
  journal={Biology of reproduction},
  year={1997},
  volume={56 6},
  pages={
          1490-7
        }
}
Treatment with cyclophosphamide, a commonly used anticancer drug, may result in oligozoospermia or azoospermia. The objective of this study was to determine whether exposure of male rats to cyclophosphamide induces apoptosis in male germ cells, and if so, when the peak of apoptosis occurs and at what specific stages of spermatogenesis. The presence of apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) detection in situ and by an increase in… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 62 CITATIONS, ESTIMATED 59% COVERAGE

Research Progress on the Biological Effects of Low-Dose Radiation in China

  • Dose-response : a publication of International Hormesis Society
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations