Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence.

@article{Ziegler1997InductionOA,
  title={Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence.},
  author={Anette-G. Ziegler and Gerd H. Luedke and Doriano Fabbro and K H Altmann and Rolf Arno Stahel and Uwe Zangemeister-Wittke},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 14},
  pages={1027-36}
}
BACKGROUND The emergence of resistance to chemotherapy remains a major problem in the treatment of patients with small-cell lung cancer. Elevated expression of Bcl-2, a protein that inhibits programmed cell death or apoptosis, has been associated with radiation and drug resistance and has been observed in the majority of small-cell lung cancer specimens and cell lines. PURPOSE To test the hypothesis that Bcl-2 expression levels are critical for inhibiting apoptosis in small-cell lung cancer… CONTINUE READING

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