Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos.

@article{Gapter2005InductionOA,
  title={Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos.},
  author={Leslie A. Gapter and Zaisen Wang and Jan A. Gliński and Ka-yun Ng},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={332 4},
  pages={
          1153-61
        }
}
Pachymic acid (PA) is a natural triterpenoid known to inhibit the phospholipase A2 (PLA(2)) family of arachidonic acid (AA)-producing enzymes. PLA(2) is elevated in prostatic adenocarcinoma and conversion of AA to prostaglandins leads to AKT pro-survival activity. In this study, we investigated the effect of PA on the growth of human prostate cancer cells. PA significantly reduced cell proliferation and induced apoptosis in a dose- and time-dependent fashion, with androgen-insensitive DU145… CONTINUE READING

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