Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha.

@article{Hernandez2003InductionOA,
  title={Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha.},
  author={Maristela de Oliveira Hernandez and Ivan Neves and Jorgenilce S Sales and Diego Soares Carvalho and Euzenir Nunes Sarno and Elizabeth Pereira Sampaio},
  journal={Immunology},
  year={2003},
  volume={109 1},
  pages={156-64}
}
A diverse range of infectious organisms, including mycobacteria, have been reported to induce cell death in vivo and in vitro. Although morphological features of apoptosis have been identified in leprosy lesions, it has not yet been determined whether Mycobacterium leprae modulates programmed cell death. For that purpose, peripheral blood mononuclear cells obtained from leprosy patients were stimulated with different concentrations of this pathogen. Following analysis by flow cytometry on 7AAD… CONTINUE READING

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