Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.

  title={Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.},
  author={Chunyao Xia and Zhidong Xu and Xiaocheng Yuan and Kazutsugu Uematsu and Liang You and Kai Li and Li Li and Frank Mccormick and David Mark Jablons},
  journal={Molecular cancer therapeutics},
  volume={1 9},
Malignant pleural mesothelioma is a rare and aggressive tumor characterized by rapid progression, late metastases, and poor prognosis. In this study, we investigated the expression of survivin, a member of the inhibitors of apoptosis protein gene family, in mesothelioma and an antisense oligonucleotide-based gene therapy for mesothelioma using survivin as a target. Initially, we documented the expression of survivin in human mesothelioma cell lines and fresh tissues using reverse transcription… CONTINUE READING


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