Induction of apoptosis in mature T cells by tumour necrosis factor

  title={Induction of apoptosis in mature T cells by tumour necrosis factor},
  author={Lixin Zheng and Galen Fisher and Robert C. Miller and Jacques J. Peschon and David H. Lynch and Michael J Lenardo},
T-CELL receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apol/CD95) and Fas ligand (FasL)1-12. Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively13,14. However, peripheral T-cell deletion takes place in lpr mice, and autoimmune syndromes occur in mouse strains without Fas or FasL defects15,16. Here we show that tumour necrosis factor (TNF) can mediate mature T-cell… CONTINUE READING
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