Induction of apoptosis in human leukaemia HL‐60 cells by furanone‐coumarins from Murraya siamensis

@article{Murata2008InductionOA,
  title={Induction of apoptosis in human leukaemia HL‐60 cells by furanone‐coumarins from Murraya siamensis},
  author={Tomiyasu Murata and Masataka Itoigawa and Chihiro Ito and Keisuke Nakao and Masaru Tsuboi and Norio Kaneda and Hiroshi Furukawa},
  journal={Journal of Pharmacy and Pharmacology},
  year={2008},
  volume={60}
}
To identify potential anti‐tumour agents, we screened five furanone‐coumarins isolated from Murraya siamensis Craib (Rutaceae) for their ability to inhibit the growth of human leukaemia HL‐60 cells. Among the furanone‐coumarins tested, murrayacoumarin B (compound 2) showed significant cytotoxicity against HL‐60 cells. Fluorescence microscopy with Hoechst 33342 staining revealed that the percentage of apoptotic cells with fragmented nuclei and condensed chromatin increased in a time‐dependent… 
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TLDR
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Current developments of coumarin compounds in medicinal chemistry.
TLDR
The whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains are presented.
[Search of novel bioactive natural products from plant sources--novel structures and biological activities--].
  • H. Furukawa
  • Chemistry, Biology
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2009
TLDR
Novel structures of acridone alkaloids, carbazole alkaloid, coumarins, depsidones, and so on isolated in the laboratory will be showed and some results of assay of biological activities of the isolated compounds will be described.
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